Description

Agilent InstantAB (formerly ProZyme) labeled N-glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS. These standards come pre-labeled with InstantAB, ready to reconstitute and inject. AdvanceBio InstantAB Human a-1-acid glycoprotein N-glycan library (formerly ProZyme). Library represents a total pool of N-linked glycans released from human a1-acid glycoprotein and labeled with InstantAB, constituting a heterogenous mixture of core non-fucosylated bi-, tri-, and tetraantennary glycans with various degrees of sialylation (NeuAc) and some with outer arm fucose residues and lactosamine repeats, consistent with N-glycans previously reported for human a1-acid glycoprotein. The biantennary glycans can have one or two sialic acid residues. The triantennary and tetraantennary glycans can have from one to four sialic acid residues and may be substituted with fucose that result in formation of sialyl Lewis X-like structure. The sialic acid residues are found both in a(2, 3) and a(2, 6) linkages. The composition of the library is approximately as follows: monosialylated glycans ~1%, di-sialylated ~20%, tri-sialylated ~51% and tetrasialylated ~27%. Triantennary glycans are a major component and constitute ~44% of total glycans present in the Human a1-acid glycoprotein N-linked Glycan Library. The reducing termini are derivatized with the fluorescent dye, InstantAB. Application: For used as a Qualitative Standard in Applications Such as Liquid Chromatography (LC) This product is only available to U.S. Domestic Customers. For research use only, not to be used in diagnostic procedures.